Patel J R, Edington N
Vet Microbiol. 1982 Sep;7(4):325-33. doi: 10.1016/0378-1135(82)90012-8.
Using indirect immunofluorescence with a hyperimmune calf serum, a virus-induced antigen was demonstrated on the surface of lymphocytes expression intracellular malignant catarrhal fever virus antigens. Antibody to the antigen was also detected in terminal sera of both cattle and rabbits. Antisera did not restrict virus expression in explanted lymph nodes unless they were supplemented with two to four units of lytic complement per ml culture. While human, bovine and guinea pig complements caused immune lysis of infected lymphocytes, rabbit complement was ineffective. The relevance of the findings in the pathogenesis of the lymphoid proliferation caused by MCFV is discussed.
使用超免疫小牛血清进行间接免疫荧光法，在表达细胞内恶性卡他热病毒抗原的淋巴细胞表面证实了一种病毒诱导抗原。在牛和兔的终末血清中也检测到了针对该抗原的抗体。抗血清不会限制外植淋巴结中的病毒表达，除非每毫升培养物中补充两到四个单位的溶细胞补体。虽然人、牛和豚鼠的补体可引起感染淋巴细胞的免疫溶解，但兔补体无效。讨论了这些发现与MCFV引起的淋巴样增殖发病机制的相关性。
