Patel J R, Edington N
J Gen Virol. 1980 Jun;48(Pt 2):437-44. doi: 10.1099/0022-1317-48-2-437.
The herpesvirus of bovine malignant catarrhal fever (MCFV, alcelaphine herpes-virus I) causes an acute, fatal lymphoproliferative disorder in rabbits. In dying rabbits, virus antigen and infectivity were associated with medium sized lymphocytes and not with theproliferative lymphoblastoid cells. Virus antigen was found diffusely in the cytoplasm and as diffuse or particulate areas in the nucleus of infected cells. Fresh suspensions of the lymphoid tissues from rabbits killed 1 to 3 days after the onset of pyrexia contained 1 to 4 of both infective and fluorescent antigen positive cells per 10(6) cells. After 2 to 3 days of culture there was a 50- to 1000-fold increase in their concentration when a similar concentration of cells also contained herpesvirus type particles, both in the cytoplasm and the nucleus. About 40- to 100-fold more antigen-positive cells developed in cultures of lymphoid tissues from rabbits killed on the 2nd or 3rd day of pyrexia compared with the cultures from rabbits killed on the first day of pyrexia. Both cytosine arabinoside and 5-iododeoxyuridine inhibited the development of the infected cells upon culture. The findings are discussed in relation to lymphoproliferative disorders caused by other herpesviruses.
牛恶性卡他热疱疹病毒（MCFV，羚羊疱疹病毒I）可在兔体内引发一种急性致命性淋巴细胞增殖性疾病。在濒死的兔中，病毒抗原和感染性与中等大小淋巴细胞相关，而非与增殖性淋巴母细胞样细胞相关。在受感染细胞中，病毒抗原弥散于细胞质中，在细胞核中则呈弥散或颗粒状区域。发热开始后1至3天处死的兔的淋巴组织新鲜悬液中，每10⁶个细胞含有1至4个感染性和荧光抗原阳性细胞。培养2至3天后，当类似浓度的细胞在细胞质和细胞核中也含有疱疹病毒样颗粒时，其浓度增加了50至1000倍。与发热第一天处死的兔的培养物相比，发热第二天或第三天处死的兔的淋巴组织培养物中产生的抗原阳性细胞多约40至100倍。阿糖胞苷和5-碘脱氧尿苷均可抑制培养时受感染细胞的发育。本文结合其他疱疹病毒引起的淋巴细胞增殖性疾病对这些发现进行了讨论。
