Mitroshina T N, Strukova S M, Umarova B A, Kudriashov B A
Vopr Med Khim. 1982 Sep-Oct;28(5):68-70.
After perfusion of rabbit carotid sinus with prethrombin 1, hypocoagulation was found in the system circulation due to reflectory reaction of the anticoagulation system. Heparin was secreted already within the first minutes of the perfusion with prethrombin 1 (1 . 10(-6) M); maximal activity of the process was observed within 5 min. Liberation of heparin from the vessel wall of carotic artery was not caused by a mechanism of local secretion, as evidenced by absence of the phenomenon in perfusion of the carotid sinus with prothrombin at molar concentration, corresponding to the concentration of prethrombin 1. Perfusion of denervated carotid sinus by means of prethrombin 1 did not stimulate the heparin secretion. Thus, the heparin secretion was regulated by a nervous mechanism, exhibiting the reflectory nature. The data obtained suggest that perfusion of the rabbit carotid sinus with prethrombin 1 stimulates the anticoagulation system and secretion of heparin.
用凝血酶原1灌注兔颈动脉窦后，由于抗凝系统的反射性反应，在体循环中发现了低凝状态。在灌注凝血酶原1（1×10⁻⁶ M）的最初几分钟内就已分泌肝素；该过程的最大活性在5分钟内观察到。从颈动脉血管壁释放肝素不是由局部分泌机制引起的，这一点由用与凝血酶原1浓度相当的摩尔浓度的凝血酶灌注颈动脉窦时未出现该现象所证明。用凝血酶原1灌注去神经的颈动脉窦不会刺激肝素分泌。因此，肝素分泌受神经机制调节，具有反射性质。所获得的数据表明，用凝血酶原1灌注兔颈动脉窦会刺激抗凝系统和肝素分泌。
