Buresová O, Semenov L V, Bures J
Acta Biol Acad Sci Hung. 1982;33(2-3):139-48.
Nausea of vestibular origin can be used instead of poisoning in the conditioned taste aversion (CTA) paradigm. In an attempt to establish the forms of vestibular stimulation best suited for inducing CTA in rats, effectiveness of 2 h rotation (Exp. 1) was compared with tonal asymmetry elicited by unilateral microinjection of 5.0 microliters of 25% KCl into the vestibular complex (Exp. 2), by unilateral electrical stimulation of vestibular nuclei (100 Hz, 1 ms, 100-200 microA, 15 min--Exp. 3) or by 10 min polarization of labyrinth through electrodes inserted in the external auditory meati (Exp. 4). Nystagmus, deviation of the head and leaning towards the blocked and away from the stimulated side were typical symptoms. When the above stimuli were applied within 10 min after saccharin drinking, galvanic stimulation was ineffective, but electrical stimulation or chemical blockade of vestibular nuclei elicited marked CTA to saccharin, considerably stronger than CTA induced by rotation. It is concluded that direct interference with the activity of vestibular nuclei elicits CTA more effectively than the stimulation of the labyrinth and is, therefore, well suited for the analytical research into the mechanisms of CTA.
在前庭性条件性味觉厌恶（CTA）范式中，可使用前庭源性恶心来替代中毒情况。为了确定最适合诱导大鼠CTA的前庭刺激形式，将2小时旋转（实验1）的效果与以下方法诱发的音调不对称进行了比较：向大鼠前庭复合体单侧微量注射5.0微升25%氯化钾诱发的音调不对称（实验2）、单侧电刺激前庭核（100赫兹，1毫秒，100 - 200微安，15分钟 - 实验3）或通过插入外耳道的电极对迷路进行10分钟极化（实验4）。眼球震颤、头部偏向受阻侧并远离刺激侧是典型症状。当在饮用糖精后10分钟内施加上述刺激时，电刺激无效，但前庭核的电刺激或化学阻断会引发对糖精明显的CTA，比旋转诱导的CTA强得多。得出的结论是，直接干扰前庭核的活动比刺激迷路更有效地引发CTA，因此非常适合对CTA机制进行分析研究。
