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高水平纯音暴露后豚鼠的耳蜗毛细胞和血管变化。

Cochlear hair cell and vascular changes in the guinea pig following high level pure-tone exposures.

作者信息

Vertes D, Nilsson P, Wersäll J, Axelsson A, Björkroth B

出版信息

Acta Otolaryngol. 1982 Nov-Dec;94(5-6):403-11. doi: 10.3109/00016488209128928.

DOI:10.3109/00016488209128928
PMID:7180415
Abstract

Noise is thought to exert metabolic and/or mechanical stress on sensory and vascular tissues of the cochlea, the relative influence of the stressors being influenced by the intensity of the noise. Guinea pigs exposed to either of two pure-tone frequencies, 1.33 or 3.85 kHz for 6 hours at intensity levels ranging from 102 dB to 120 dB SPL, were studied for pathological changes in two spiral lamina vessels--the vessel of the basilar membrane (VSBM) and the vessel of the tympanic lip (VSTL). In general, animals sustaining mild to severe degrees of hair cell destruction one month after noise exposure showed little vascular change in the vessels studied. With respect to the vasculature, the concept of a 'critical level' seems to be dependent on exposure frequency, in that only above 117 dB SPL at 3.85 kHz was there any change in the pattern of damage to the spiral lamina vessels.

摘要

噪声被认为会对耳蜗的感觉和血管组织施加代谢和/或机械应力,这些应激源的相对影响受噪声强度的影响。研究了豚鼠在102分贝至120分贝声压级范围内,暴露于1.33千赫或3.85千赫这两种纯音频率中的任意一种6小时后,两个螺旋板层血管——基底膜血管(VSBM)和鼓唇血管(VSTL)的病理变化。一般来说,噪声暴露一个月后遭受轻度至重度毛细胞破坏的动物,在所研究的血管中几乎没有血管变化。关于脉管系统,“临界水平”的概念似乎取决于暴露频率,因为只有在3.85千赫时声压级高于117分贝时,螺旋板层血管的损伤模式才会有任何变化。

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