Thorne P R, Nuttall A L
Hear Res. 1987;27(1):1-10. doi: 10.1016/0378-5955(87)90021-9.
This investigation examined the effects of loud sound of different frequencies and intensities on cochlear blood flow as measured by the laser Doppler flowmeter. Cochlear blood flow was measured in anesthetized guinea pigs during a 1 h exposure to either a 2, 4, or 12 kHz pure tone or high-pass noise (10-40 kHz) at 90, 103, or 110 dB SPL. Cochlear function was assessed using the compound action potential audiogram before and after exposure. There was no change in blood flow in the second turn with a 2, 4, or 12 kHz tone but there was a significant (P less than 0.05) decline in flow in the first cochlear turn at the end of either the 12 kHz tone or high-pass noise exposure at 103 and 110 dB SPL. There were elevations in the thresholds of the cochlear compound action potential after all but the 90 dB exposures to 12 kHz or high-pass noise. No such changes were observed in blood flow or electrophysiology in control animals. These findings demonstrate that there is a small but significant decline in cochlear blood flow with high intensity sound exposure. However, the relationship between this change in blood flow and the development of cochlear damage is unclear.
本研究通过激光多普勒血流仪检测了不同频率和强度的大声响对耳蜗血流的影响。在麻醉的豚鼠暴露于2、4或12千赫纯音或90、103或110分贝声压级的高通噪声（10 - 40千赫）1小时期间，测量耳蜗血流。在暴露前后使用复合动作电位听力图评估耳蜗功能。2、4或12千赫音调刺激时第二圈血流无变化，但在12千赫音调或103和110分贝声压级的高通噪声暴露结束时，第一耳蜗圈血流显著（P小于0.05）下降。除了90分贝暴露于12千赫或高通噪声外，所有其他暴露后耳蜗复合动作电位阈值均升高。在对照动物中未观察到血流或电生理学的此类变化。这些发现表明，高强度声音暴露会使耳蜗血流出现小但显著的下降。然而，这种血流变化与耳蜗损伤发展之间的关系尚不清楚。
