Elbaz P
Ann Otolaryngol Chir Cervicofac. 1978 Apr-May;95(4-5):315-20.
Otomycoses account for approximately 20 % of cases of otitis externa. Often unrecognised, they may be induced by various factors, in particular local antibiotic and corticosteroid therapy. The authors studied the effectiveness and tolerance of Econazole (1 % milk) in the treatment of otomycoses. In each of 30 cases, a bacteriological examination was made before and one week after treatment, the latter consisting of the insertion into the E.A.M. of a wick soaked in Econazole (1 % milk) every night. From a mycological standpoint, the fungus disappeared in all cases. Clinically, in relation to the criteria of assessment, a successful result was recorded in 28 cases out of 30. In 87 % of cases, cure was obtained in less than 2 weeks, and apart from a transient and brief subjective sensation of an increase in certain symptoms (17 %), tolerance was perfect. Econazole (1 % milk) would appear to be the drug of choice in the treatment of otomycoses of the E.A.M., being effective against the fungi usually responsible (Aspergillus niger, fumigatus, flavus, Candida albicans, krusei etc.), as well as having a bactericidal action against Gram + bacteria.
耳霉菌病约占外耳道炎病例的20%。它们常常未被识别,可能由多种因素诱发,特别是局部使用抗生素和皮质类固醇治疗。作者研究了益康唑(1%乳剂)治疗耳霉菌病的有效性和耐受性。在30例患者中,每例在治疗前和治疗一周后均进行了细菌学检查,治疗是每晚将浸有益康唑(1%乳剂)的棉芯插入外耳道。从真菌学角度来看,所有病例中的真菌均消失。临床上,根据评估标准,30例中有28例取得了成功结果。在87%的病例中,不到2周即治愈,除了某些症状出现短暂且轻微的主观加重感(17%)外,耐受性良好。益康唑(1%乳剂)似乎是治疗外耳道耳霉菌病的首选药物,它对通常致病的真菌(黑曲霉、烟曲霉、黄曲霉、白色念珠菌、克柔念珠菌等)有效,同时对革兰氏阳性菌有杀菌作用。