Baum M
Ann R Coll Surg Engl. 1978 Nov;60(6):479-82.
The rationale of the conventional treatment of carcinoma of the breast by radical mastectomy is examined and is shown, in the light of modern concepts of the biology of the disease, to be faulty. It is proposed that the primary management of breast cancer should have three aims--preoperative diagnosis so that mastectomy may be avoided in patients with overtly disseminated disease, adequate local control of the disease with the maintenance of good life quality, and staging by minimal examination of the axillary contents or pectoral node biopsy as a guide to such adjuvant systemic therapy as may prove necessary.
对通过根治性乳房切除术治疗乳腺癌的传统疗法的基本原理进行了审视,并根据该疾病生物学的现代概念表明其存在缺陷。建议乳腺癌的主要治疗应具有三个目标:术前诊断,以便在有明显播散性疾病的患者中避免乳房切除术;对疾病进行充分的局部控制并维持良好的生活质量;通过对腋窝内容物进行最少检查或胸肌淋巴结活检进行分期,以此作为可能必要的辅助全身治疗的指导。