辛辛那提脂质研究诊所家族研究：脂质和脂蛋白浓度的文化与生物学决定因素
The Cincinnati Lipid Research Clinic family study: cultural and biological determinants of lipids and lipoprotein concentrations.
作者信息
Rao D C, Laskarzewski P M, Morrison J A, Khoury P, Kelly K, Wette R, Russell J, Glueck C J
出版信息
Am J Hum Genet. 1982 Nov;34(6):888-903.
Abstract
A general linear model is described here for cultural and biological inheritance of lipids and lipoproteins. This model involves 10 parameters to be estimated from a total of 17 correlations, leaving ample degrees of freedom to test the goodness of fit. The model fits very well to each of the five lipid and lipoprotein variables analyzed here from a Lipid Research Clinic family data set. Both genetic and cultural inheritance are significant for each trait with the single exception that triglyceride levels fail to support genetic inheritance. Under the most parsimonious hypothesis, the genetic heritability (h2) ranges from .194 +/- .092 for triglyceride to .624 +/- .093 for low-density lipoprotein-cholesterol. Cultural heritability ranges from .070 +/- .030 for total cholesterol to .149 +/- .034 for triglyceride.
摘要
本文描述了一个用于脂质和脂蛋白的文化与生物遗传的一般线性模型。该模型涉及10个需从总共17个相关性中估计的参数，从而为检验拟合优度留出了充足的自由度。该模型与脂质研究诊所家庭数据集里分析的五个脂质和脂蛋白变量中的每一个都拟合得非常好。除甘油三酯水平不支持遗传继承这一唯一例外，遗传和文化继承对每个性状都很显著。在最简约的假设下，遗传遗传力（h2）范围从甘油三酯的0.194±0.092到低密度脂蛋白胆固醇的0.624±0.093。文化遗传力范围从总胆固醇的0.070±0.030到甘油三酯的0.149±0.034。
相似文献
1
2
Cultural and biological determinants of lipoprotein concentrations.
Ann Hum Genet. 1979 May;42(4):467-77. doi: 10.1111/j.1469-1809.1979.tb00680.x.
3
Biological and environmental sources of variation in plasma lipids and lipoproteins: the Jerusalem Lipid Research Clinic.
Hum Hered. 1986;36(3):143-53. doi: 10.1159/000153618.
4
The Cincinnati Lipid Research Clinic Family Study: commingling in the distributions of lipids and lipoprotein concentrations.辛辛那提脂质研究诊所家族研究：脂质和脂蛋白浓度分布中的混合分析
Hum Hered. 1983;33(4):223-30. doi: 10.1159/000153382.
5
Heterogeneity between populations for multifactorial inheritance of plasma lipids.人群中血浆脂质多因素遗传的异质性。
Am J Hum Genet. 1983 May;35(3):468-83.
6
Biological and cultural sources of familial resemblance in plasma lipids: a comparison between North America and Israel--the Lipid Research Clinics Program.
Genet Epidemiol. 1988;5(1):17-33. doi: 10.1002/gepi.1370050103.
7
Genetic and environmental determinants of serum lipids and lipoproteins in French Canadian families.
Arteriosclerosis. 1989 May-Jun;9(3):308-18. doi: 10.1161/01.atv.9.3.308.
8
Family resemblance for plasma lipids and lipoprotein concentrations in blacks. Cincinnati Lipid Research Clinic Family Study.黑人血浆脂质和脂蛋白浓度的家族相似性。辛辛那提脂质研究诊所家族研究。
Arteriosclerosis. 1984 Jan-Feb;4(1):65-9. doi: 10.1161/01.atv.4.1.65.
9
Heterogeneity in the biological and cultural determinants of high-density lipoprotein cholesterol in five North American populations: the Lipid Research Clinics Family Study.北美五个人群中高密度脂蛋白胆固醇生物学和文化决定因素的异质性：脂质研究诊所家族研究
Hum Hered. 1989;39(5):249-57. doi: 10.1159/000153868.
10
Heterogeneity in multifactorial inheritance of plasma lipids and lipoproteins in ethnically diverse families in Jerusalem.
Genet Epidemiol. 1986;3(2):95-112. doi: 10.1002/gepi.1370030205.
引用本文的文献
1
Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits.对西班牙裔/拉丁裔人群的大规模多组学分析确定了心血管代谢特征的相关基因。
Nat Commun. 2025 Apr 11;16(1):3438. doi: 10.1038/s41467-025-58574-z.
2
Role of non-coding variants in cardiovascular disease.非编码变异在心血管疾病中的作用。
J Cell Mol Med. 2023 Jun;27(12):1621-1636. doi: 10.1111/jcmm.17762. Epub 2023 May 15.
3
Rare non-coding variants are associated with plasma lipid traits in a founder population.在一个奠基人群体中，罕见的非编码变异与血浆脂质特征相关。
Sci Rep. 2017 Nov 27;7(1):16415. doi: 10.1038/s41598-017-16550-8.
4
Genetic architecture of lipid traits changes over time and differs by race: Princeton Lipid Follow-up Study.脂质性状的遗传结构随时间变化且因种族而异：普林斯顿脂质随访研究。
J Lipid Res. 2014 Jul;55(7):1515-24. doi: 10.1194/jlr.M049932. Epub 2014 May 25.
5
Use of systems biology approaches to analysis of genome-wide association studies of myocardial infarction and blood cholesterol in the nurses' health study and health professionals' follow-up study.在护士健康研究和卫生专业人员随访研究中，运用系统生物学方法分析心肌梗死和血液胆固醇的全基因组关联研究。
PLoS One. 2013 Dec 26;8(12):e85369. doi: 10.1371/journal.pone.0085369. eCollection 2013.
6
Blood lipids, infection, and inflammatory markers in the Tsimane of Bolivia.玻利维亚提斯曼人的血脂、感染和炎症标志物。
Am J Hum Biol. 2010 Nov-Dec;22(6):731-40. doi: 10.1002/ajhb.21074.
7
Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.血浆高密度脂蛋白胆固醇与冠状动脉粥样硬化严重程度的候选基因分析
BMC Med Genet. 2009 Oct 30;10:111. doi: 10.1186/1471-2350-10-111.
8
An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study.降脂药物效果的调查：HyperGEN研究中血脂的全基因组连锁分析
BMC Genet. 2007 Sep 10;8:60. doi: 10.1186/1471-2156-8-60.
9
Design of a family study among high-risk Caribbean Hispanics: the Northern Manhattan Family Study.高危加勒比裔西班牙裔人群家庭研究的设计：北曼哈顿家庭研究
Ethn Dis. 2007 Spring;17(2):351-7.
10
A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.一系列前蛋白转化酶枯草溶菌素9（PCSK9）等位基因影响低密度脂蛋白胆固醇的血浆水平。
Am J Hum Genet. 2006 Mar;78(3):410-22. doi: 10.1086/500615. Epub 2006 Jan 20.
本文引用的文献
1
Determinants of blood pressure in Japanese-American Families.日裔美国家庭中血压的决定因素。
Hum Genet. 1980 Feb;53(2):261-6. doi: 10.1007/BF00273508.
2
Lipoprotein-cholesterol distributions in selected North American populations: the lipid research clinics program prevalence study.北美特定人群中的脂蛋白胆固醇分布：脂质研究诊所项目患病率研究
Circulation. 1980 Feb;61(2):302-15. doi: 10.1161/01.cir.61.2.302.
3
Parent-offspring and sibling lipid and lipoprotein associations during and after sharing of household environments: the Princeton school district family study.
Metabolism. 1982 Feb;31(2):158-66. doi: 10.1016/0026-0495(82)90129-9.
4
Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia.冠心病中的高脂血症。II. 176个家族血脂水平的遗传分析及一种新的遗传性疾病——混合型高脂血症的描述
J Clin Invest. 1973 Jul;52(7):1544-68. doi: 10.1172/JCI107332.
5
Parent-child associations at upper and lower ranges of plasma cholesterol and triglyceride levels.
Pediatrics. 1978 Oct;62(4):468-77.
6
Behavioral, social, and physiological determinants of lipoprotein concentrations.
Soc Biol. 1977 Winter;24(4):289-93. doi: 10.1080/19485565.1977.9988299.
7
Genetic and environmental determinants of periodontal disease.牙周病的遗传和环境决定因素。
Am J Med Genet. 1979;4(1):39-45. doi: 10.1002/ajmg.1320040106.
8
Determinants of plasma uric acid.
Hum Genet. 1979 Sep;50(3):307-12. doi: 10.1007/BF00399397.
9
Path analysis under generalized assortative mating. I. Theory.广义选型交配下的通径分析。I. 理论
Genet Res. 1979 Apr;33(2):175-88. doi: 10.1017/s0016672300018310.
10
Cultural and biological determinants of lipoprotein concentrations.
Ann Hum Genet. 1979 May;42(4):467-77. doi: 10.1111/j.1469-1809.1979.tb00680.x.
Zotero 插件