Laskarzewski P M, Glueck C J, Rao D C
Arteriosclerosis. 1984 Jan-Feb;4(1):65-9. doi: 10.1161/01.atv.4.1.65.
Our specific aim in this study was to assess the family resemblance for lipids and lipoproteins in blacks randomly selected from the Princeton School District's Family Study cohort, and compare the family resemblance of lipids and lipoproteins between the blacks and whites from the same cohort. There were 160 white and 59 black nuclear families ascertained through randomly selected family study probands. Familial correlations were estimated by the method of maximum likelihood. Father-child and sib-sib correlations were of larger magnitude in whites than blacks for each lipid and lipoprotein, with the exception of high density lipoprotein cholesterol, where the correlations in blacks were higher than in whites. Estimates of genetic heritability were larger in whites than in blacks for each lipid and lipoprotein, with the exception of high density lipoprotein cholesterol. Whereas environment has a substantial effect on high density lipoprotein cholesterol levels in both blacks and whites, there may be a greater genetic effect accounting for higher levels of high density lipoprotein cholesterol in blacks. This is highlighted in our current study by the consistent observation in blacks of increased measures of within-family resemblance for high density lipoprotein cholesterol alone, of all lipids and lipoproteins.
我们在本研究中的具体目标是评估从普林斯顿学区家庭研究队列中随机选取的黑人中脂质和脂蛋白的家族相似性，并比较同一队列中黑人和白人之间脂质和脂蛋白的家族相似性。通过随机选择的家庭研究先证者确定了160个白人核心家庭和59个黑人核心家庭。采用最大似然法估计家族相关性。对于每种脂质和脂蛋白，白人中父子和同胞之间的相关性在幅度上大于黑人，但高密度脂蛋白胆固醇除外，其在黑人中的相关性高于白人。对于每种脂质和脂蛋白，白人中的遗传遗传度估计值大于黑人，但高密度脂蛋白胆固醇除外。虽然环境对黑人和白人的高密度脂蛋白胆固醇水平都有显著影响，但可能存在更大的遗传效应导致黑人中高密度脂蛋白胆固醇水平更高。在我们目前的研究中，这一点得到了突出体现，即在所有脂质和脂蛋白中，仅在黑人中一致观察到高密度脂蛋白胆固醇的家庭内相似性测量增加。
