Tryba M, Yildiz F, Zenz M, Schwerdt M
Anaesthesist. 1982 Oct;31(10):584-7.
Aspiration of gastric acid is one of the most feared narcosis complications. The currently practiced methods of prophylaxis did not reduce the frequency of aspiration pneumonitis. In a prospective randomised study orally and intramuscularly given Cimetidine significantly reduced the toxicity of stomach contents. The intramuscular route proved to be superior. Preoperative prophylactic use of Cimetidine can be a useful method to reduce the frequency of Mendelson's syndrome without disadvantages.
胃酸误吸是最令人担忧的麻醉并发症之一。目前采用的预防方法并未降低误吸性肺炎的发生率。在一项前瞻性随机研究中,口服和肌肉注射西咪替丁可显著降低胃内容物的毒性。结果证明肌肉注射途径更具优势。术前预防性使用西咪替丁可能是一种有用的方法,可降低门德尔松综合征的发生率且无不良影响。