Breznock E M, Strack D
Am J Vet Res. 1982 Nov;43(11):2062-6.
Blood volume (BV), RBC mass, plasma protein (PP), and PCV were determined in (i) awake, nonsplenectomized (NSPX) cats before and after splenic contraction was induced by IV administration of epinephrine, (ii) in pentobarbital-anesthetized, NSPX cats before and after splenic contraction was induced by epinephrine and splenectomy, and (iii) in awake, splenectomized (SPX) cats before and after epinephrine was administered. Blood volume, absolute RBC mass in the spleen could not be determined accurately in awake or anesthetized, NSPX cats. Accurate BV and RBC mass determinations could only be obtained in cats without the spleen; mean BV and RBC mass of awake or anesthetized, SPX cats were 4.1% and 1.4% or body weight, respectively. The spleen was a dynamic sequestering organ for feline erythrocytes (RBC). Epinephrine (0.1 ml of 1:1,000) given IV resulted in the observed contraction of the spleen within 2 minutes. Relaxation of the spleen with RBC uptake began 3 minutes after epinephrine was given and it proceeded at a rate of approximately 0.93% of circulating PCV/min. At 20 minutes after epinephrine was given, a steady state of PCV occurred, and 20% of the maximum circulating PCV observed after the administration of epinephrine was stored within the spleen. At 60 minutes after epinephrine was given to awake, SPX cats, intravascular fluid influx of 4 ml/kg resulted in a decrease of PCV and PP. At 3 hours after splenectomy was done, intravascular fluid efflux resulted in hemoconcentration--a calculated fluid deficit of 2.5 ml/kg/hr occurring during the 3 hours after surgical removal of the spleen.
对以下几种猫进行了血容量（BV）、红细胞质量、血浆蛋白（PP）和血细胞比容（PCV）的测定：（i）清醒、未行脾切除术（NSPX）的猫，静脉注射肾上腺素诱导脾收缩前后；（ii）戊巴比妥麻醉、NSPX的猫，肾上腺素诱导脾收缩前后以及脾切除术后；（iii）清醒、行脾切除术（SPX）的猫，注射肾上腺素前后。在清醒或麻醉的NSPX猫中，无法准确测定血容量以及脾脏中的绝对红细胞质量。只有在无脾的猫中才能准确测定BV和红细胞质量；清醒或麻醉的SPX猫的平均BV和红细胞质量分别为体重的4.1%和1.4%。脾脏是猫红细胞（RBC）的一个动态潴留器官。静脉注射肾上腺素（0.1 ml的1:1000溶液）可在2分钟内使脾脏收缩。注射肾上腺素3分钟后脾脏开始舒张并摄取红细胞，摄取速率约为循环PCV的0.93%/分钟。注射肾上腺素20分钟后，PCV达到稳定状态，注射肾上腺素后观察到的最大循环PCV的20%储存在脾脏中。给清醒的SPX猫注射肾上腺素60分钟后，4 ml/kg的血管内液体流入导致PCV和PP降低。脾切除术后3小时，血管内液体流出导致血液浓缩——脾切除术后3小时内计算得出的液体缺失为2.5 ml/kg/小时。
