Fuzibet J G, Squara P, Verdier J M, Lapalus P, Gratecos N, Cassuto J P, Chichmanian R M, Dujardin P
Ann Med Interne (Paris). 1982;133(6):410-5.
In spite of the development in cases of deep mycoses, cases of osteoarthritis with Candida remain rare (only thirty seven cases reported). Among these, ten observations of spondylodiscitis have been collected and the authors report a new case where Candida albicans was isolated in the discovertebral focus through bone puncture. This spondylodiscitis occurring in a leukemic patient receiving antibiotics, corticosteroids, cytostatics drugs and radiotherapy, was treated successfully by an association of Amphotericin B-5-Fluorocytosine. The authors take this opportunity to report the main characteristics of the ten previously described cases specifying the rules for the uses of fungicidal drugs in the treatment of deep mycoses and for the first time, they study simultaneously seric concentration, penetration into healthy bone and into discovertebral focus of the 5-Fluorocytosine. They also justify their preference for the association of Amphotericin B-5-Fluorocytosine as a "first line" treatment after confirming the sensitivity of the strain to 5-Fluorcytosine.
尽管深部真菌病的病例有所增加，但念珠菌性骨关节炎病例仍然罕见（仅报告了37例）。其中，已收集到10例脊椎间盘炎的观察结果，作者报告了1例新病例，通过骨穿刺在椎间盘病灶中分离出白色念珠菌。该脊椎间盘炎发生在一名接受抗生素、皮质类固醇、细胞毒性药物和放射治疗的白血病患者身上，通过两性霉素B-5-氟胞嘧啶联合治疗成功治愈。作者借此机会报告了先前描述的10例病例的主要特征，详细说明了在深部真菌病治疗中使用杀真菌药物的规则，并且首次同时研究了5-氟胞嘧啶的血清浓度、在健康骨骼和椎间盘病灶中的渗透情况。在确认菌株对5-氟胞嘧啶敏感后，他们还说明了优先选择两性霉素B-5-氟胞嘧啶联合治疗作为“一线”治疗方案的理由。
