Lilien L D, Ramamurthy R S, Pildes R S
Pediatrics. 1978 Jan;61(1):57-61.
Candida albicans meningitis was diagnosed in a 45-day-old premature infant whose birth weight was 1,616 gm. Symptoms consisted of poor weight gain and poor suckling. The combined use of amphotericin B and 5-fluorocytosine (5-FC) resulted in negative CSF cultures after 12 days of therapy. Amphotericin B was given for 45 days (total 83 mg) and 5-FC for 60 days (total 19 mg). Only one other premature infant has been reported in the literature who had similar treatment. A review of Candida meningitis diagnosed before death in 11 other infants less than 1 year of age is presented.
一名出生体重为1616克的45天大的早产儿被诊断为白色念珠菌性脑膜炎。症状包括体重增加缓慢和吸吮无力。两性霉素B和5-氟胞嘧啶（5-FC）联合使用，治疗12天后脑脊液培养结果转阴。两性霉素B使用了45天（总量83毫克），5-FC使用了60天（总量19毫克）。文献中仅报道过另外一名接受类似治疗的早产儿。本文还对另外11名1岁以下在死亡前被诊断为念珠菌性脑膜炎的婴儿进行了综述。
