Coppola A, Rao S
Ann Clin Lab Sci. 1982 Nov-Dec;12(6):471-6.
The case is described of a low birth weight infant who developed severe neutropenia, thrombocytopenia and monocytosis in the course of staphylococcal septicemia. Light microscopy examination of the blood revealed bacteria inside the monocytes. On electron microscopy, the monocytes were degranulated and distorted by the presence of large vacuoles containing bacteria. While most of the bacteria were intact, some showed capsular dissolution suggesting the effect of lysosomes. Rarely, the bacteria were also noted within the polymorphonuclear leukocytes and platelets. Based on the finding of electron microscopy in this case, the phagocytic function of the monocytes, neutrophils and possibly the platelets was intact. In view of the fatal outcome, despite the previous findings, it is suggested that granulocyte transfusion be considered in low birth weight infants with persistent sepsis.
本文描述了一例低体重儿，其在葡萄球菌败血症病程中出现严重中性粒细胞减少、血小板减少和单核细胞增多。血液光镜检查显示单核细胞内有细菌。电子显微镜检查发现，单核细胞因含有细菌的大空泡而脱颗粒且形态扭曲。虽然大多数细菌完整，但有些显示出荚膜溶解，提示有溶酶体的作用。很少见的是，在多形核白细胞和血小板内也发现了细菌。基于该病例的电子显微镜检查结果，单核细胞、中性粒细胞以及可能还有血小板的吞噬功能是完整的。鉴于尽管有先前的检查结果但仍出现了致命结局，建议对患有持续性败血症的低体重儿考虑进行粒细胞输注。
