胆囊切除术患者胆囊胆汁中头孢西丁的浓度。
Concentrations of cefoxitin in gallbladder bile of cholecystectomy patients.
作者信息
Hansbrough J F, Clark J E
出版信息
Antimicrob Agents Chemother. 1982 Oct;22(4):709-10. doi: 10.1128/AAC.22.4.709.
Abstract
Cefoxitin was administered in a dose of 2 g intravenously to 17 patients scheduled for cholecystectomy. The concentrations of this agent in serum and gallbladder bile were measured simultaneously upon opening of the abdominal cavity. Concentrations of cefoxitin in excess of 10 microgram/ml were present in the gallbladder bile of 12 of the 13 patients from samples obtained between 35 and 165 min after cefoxitin infusion. Cystic or common duct obstruction did not preclude entry of the drug into gallbladder bile.
摘要
对17例计划进行胆囊切除术的患者静脉注射2克头孢西丁。在打开腹腔时同时测量该药物在血清和胆囊胆汁中的浓度。在头孢西丁输注后35至165分钟之间采集的样本中，13例患者中有12例的胆囊胆汁中头孢西丁浓度超过10微克/毫升。胆囊管或胆总管梗阻并不妨碍药物进入胆囊胆汁。
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