[Immunodepressive action and effects of medroxyprogesterone acetate on the lymphatic tissue of the spleen of rabbits].

Present results demonstrated that medroxyprogesterone acetate (MPA) caused depletion of lymphoid splenic tissue in rabbits. This phenomenon, induced by corticoid action and antiproliferative activity of the hormonal agent, supported the immunodepressive properties of drug, which prolonged the survival of some allografts and lowered the antibody response to different antigens.