Cherubino P, Bianchi A, Arnaboldi A, Santamaria L
Arch Sci Med (Torino). 1982 Jul-Sep;139(3):279-86.
Muscle lesions induced by ischaemia have been investigated in depth from the morphological standpoint, though the metabolic changes thus caused are still the subjects of discussion. Measurements were therefore made of enzyme activities in rat calf muscle, and their changes following incomplete ischaemia. Three enzymes were studied: CPK (typical of muscle metabolism), G-6-PDH (pentose cycle, indicator of the extent of repair processes), and uptake of a labelled amino acid (L-leucine, on the part of tissue proteins. An initial increase in activity and uptake was followed by recovery functions, due to installation of a collateral circulation. This appeared to be complete by the 5th day.
从形态学角度对缺血诱导的肌肉损伤进行了深入研究，不过由此引起的代谢变化仍是讨论的话题。因此，对大鼠小腿肌肉中的酶活性及其在不完全缺血后的变化进行了测量。研究了三种酶：肌酸磷酸激酶（CPK，肌肉代谢的典型指标）、葡萄糖-6-磷酸脱氢酶（G-6-PDH，戊糖循环，修复过程程度的指标）以及标记氨基酸（L-亮氨酸，用于检测组织蛋白摄取情况）。由于侧支循环的建立，活性和摄取最初会增加，随后恢复正常功能。到第5天时，这种恢复似乎已完成。
