Lupien P J, Moorjani S, Gagne C, Brun L D, Lou M, Dagenais G
Artery. 1982;10(4):286-300.
Two familial hypercholesterolemic heterozygote patients were treated for a period of 2 years using an extracorporeal technique involving batch affinity chromatography. In both cases LDL-cholesterol levels were drastically lowered and HDL-cholesterol levels were normalized. No untoward side effects were noted during the 2 year experimental period. These results confirm the safety and simplicity of this technique to lower considerably LDL-cholesterol levels in whole blood of familial hypercholesterolemic patients who do not adequately respond to conventional medical treatment.
两名家族性高胆固醇血症杂合子患者采用涉及批量亲和色谱的体外技术进行了为期2年的治疗。在这两个病例中，低密度脂蛋白胆固醇水平大幅降低，高密度脂蛋白胆固醇水平恢复正常。在2年的实验期内未观察到不良副作用。这些结果证实了该技术在对传统药物治疗反应不佳的家族性高胆固醇血症患者全血中显著降低低密度脂蛋白胆固醇水平方面的安全性和简便性。
