Parker T S, Gordon B R, Saal S D, Rubin A L, Ahrens E H
Proc Natl Acad Sci U S A. 1986 Feb;83(3):777-81. doi: 10.1073/pnas.83.3.777.
Plasma high density lipoprotein (HDL) concentrations were increased in five hypercholesterolemic normoglyceridemic patients after removal of plasma low density lipoprotein (LDL) by LDL-pheresis. In each patient up to 80% of circulating LDL was removed by passing plasma through immunoadsorption columns containing antibody to apolipoprotein B immobilized to Sepharose. Rebound of LDL was slow after the procedure: 5-7 days in four non-familial hypercholesterolemic patients and greater than 14 days in one patient with homozygous familial hypercholesterolemia. Plasma HDL rose above the pretreatment baseline during the interval between treatments in four of the five patients. When treatments were repeated weekly, time-averaged plasma LDL was lowered by 40-70%, while plasma HDL cholesterol and apolipoprotein AI were increased up to 2-fold, depending on the degree of LDL lowering. Plasma HDL concentrations fell back to their baseline values when LDL-pheresis was stopped and rose again when treatment was restarted. Thus, LDL-pheresis may augment the therapeutic effectiveness of LDL lowering by raising plasma HDL levels and the concentration of HDL relative to LDL.
通过低密度脂蛋白（LDL）吸附去除术去除五名高胆固醇血症且甘油三酯正常患者的血浆低密度脂蛋白后，其血浆高密度脂蛋白（HDL）浓度升高。通过使血浆通过含有固定于琼脂糖上的载脂蛋白B抗体的免疫吸附柱，每名患者循环中的LDL最多可去除80%。术后LDL的反弹较慢：四名非家族性高胆固醇血症患者为5 - 7天，一名纯合子家族性高胆固醇血症患者则超过14天。五名患者中有四名患者在两次治疗的间隔期内，血浆HDL升至治疗前基线水平之上。当每周重复进行治疗时，根据LDL降低的程度，时间平均血浆LDL降低40% - 70%，而血浆HDL胆固醇和载脂蛋白AI增加至两倍。当停止LDL吸附去除术时，血浆HDL浓度回落至基线值，重新开始治疗时又再次升高。因此，LDL吸附去除术可能通过提高血浆HDL水平以及HDL相对于LDL的浓度来增强降低LDL的治疗效果。
