Núñez-Durán H, Ubaldo E
Artery. 1982;10(4):301-7.
Femoral artery of the rat was percutaneously damaged with ultrasound (20kHz, 20 watts, 20 sec.). The arterial wall close to the irradiation source was injured whereas the opposite wall survived. The sequence of events showed that 1 h. after the sonication the smooth muscle cells have become paralyzed and the endothelium was injured in a patchy way. These cells desquamated 1-4 hours after the injury while the smooth muscle cells became severely altered. Twelve hours after the injury the endothelium has disrupted and the media has been completely injured, but the internal elastic lamina and the intimal connective tissue were undamaged and were coated with activated platelets. This procedure to injure locally the intima may be very useful to carry on further studies on activation of platelets "in vivo" or on intimal healing.
用超声（20kHz，20瓦，20秒）经皮损伤大鼠股动脉。靠近照射源的动脉壁受损，而对侧动脉壁存活。事件序列显示，超声处理后1小时，平滑肌细胞麻痹，内皮呈片状损伤。这些细胞在损伤后1 - 4小时脱落，平滑肌细胞则发生严重改变。损伤后12小时，内皮破裂，中膜完全受损，但内弹性膜和内膜结缔组织未受损，表面覆盖有活化血小板。这种局部损伤内膜的方法对于进一步开展关于“体内”血小板活化或内膜愈合的研究可能非常有用。
