Chen L E, Seaber A V, Glisson R R, Mikat E M, Urbaniak J R
Orthopaedic Research Laboratories, Duke University Medical Center, Durham, NC 27710.
Microsurgery. 1991;12(6):402-11. doi: 10.1002/micr.1920120607.
Replantation after crush amputation has a relatively low success rate. An arterial crush injury was produced in rats under a range of pressure (8.5 to 2,551 g/mm2) and durations (10 to 60 minutes). The degrees of vessel injury and thrombus formation were evaluated as functions of both crush force and duration, and the healing process was followed for 8 weeks. Crushing resulted in morphologic damage to the arterial wall but did not impair patency. Damage was directly proportional to crush pressure and duration. Intimal denudation caused flat platelet adhesion but no thrombus formation or thrombosis. Re-endothelialization was completed by 2 weeks. Intimal hyperplasia appeared at 1 week and consisted of endothelia in the most luminal layers and smooth muscle in the deeper layers. the internal elastic lamina was intact in all specimens and was thought to minimize platelet aggregation on the arterial wall after denudation of the intima.
挤压离断伤再植术后成功率相对较低。在一系列压力（8.5至2551克/平方毫米）和持续时间（10至60分钟）下对大鼠造成动脉挤压伤。评估血管损伤程度和血栓形成情况与挤压力和持续时间的关系，并随访8周观察愈合过程。挤压导致动脉壁形态学损伤，但未影响通畅性。损伤程度与挤压压力和持续时间成正比。内膜剥脱导致血小板扁平黏附，但未形成血栓或发生血栓形成。2周时完成再内皮化。内膜增生在1周时出现，最内层为内皮细胞，较深层为平滑肌细胞。所有标本的内弹性膜均完整，被认为可使内膜剥脱后动脉壁上的血小板聚集降至最低。
