Milhaud G, Labat M L, Moricard Y
Biomed Pharmacother. 1982;36(8-9):360-5.
Adjuvant arthritis stands as the closest model to human rheumatoid arthritis. A genetic mutation (op) recognized to provoke osteopetrosis in rats, completely inhibits their ability to develop adjuvant arthritis. Osteopetrosis in the op mutant is linked to deficiencies in T-lymphocytes and macrophages functions. Therefore this animal model may be helpful for a better understanding of the immunoregulation impairment involved in adjuvant arthritis.
佐剂性关节炎是最接近人类类风湿性关节炎的模型。一种已知会在大鼠中引发骨质硬化的基因突变（op），完全抑制了它们发展佐剂性关节炎的能力。op突变体中的骨质硬化与T淋巴细胞和巨噬细胞功能缺陷有关。因此，这个动物模型可能有助于更好地理解佐剂性关节炎中涉及的免疫调节损伤。
