Labat M L
Biomed Pharmacother. 1986;40(3):85-90.
Since decades, retroviruses are known to induce the formation of dense bones (osteopetrosis) in animals, either by increasing osteoblastic proliferation (ALVs viruses) or by decreasing osteoclastic bone resorption (FeLV virus). The latter is a good model of the inherited disease since neonatally infected cats die from wasting disease, like mutant op/op rats and children suffering from juvenile-malignant osteopetrosis. These similarities have prompted this review of retrovirus-induced osteopetrosis in animals. We suggest the possibility that retroviruses might be involved, at least in part, in the induction of the human disease.
几十年来，人们已知逆转录病毒可在动物体内诱导形成致密骨（骨质石化），其方式要么是增加成骨细胞增殖（禽白血病病毒），要么是减少破骨细胞的骨吸收（猫白血病病毒）。后者是遗传性疾病的一个良好模型，因为新生期感染的猫会死于消耗性疾病，就像op/op突变大鼠和患有青少年恶性骨质石化的儿童一样。这些相似之处促使我们对动物中逆转录病毒诱导的骨质石化进行综述。我们认为逆转录病毒可能至少在一定程度上参与了人类疾病的诱发。
