Wennersten G, Brunk U
Acta Derm Venereol. 1977;57(3):201-9.
Kynurenic acid is an endogenously occurring tryptophan metabolite, which, under certain conditions, may accumulate in human tissues. In earlier work kynurenic acid showed a pronounced photohemolytic capacity, and conclusive evidence has been presented that the reaction is mediated by singlet oxygen. The aim of the present study was to gain further information about the cellular mechanisms involved in the photo-oxidative damage induced by kynurenic acid. This paper is mainly concerned with the establishment of a proper experimental model utilizing in vitro cultivated cells, but basal cytotoxic effects revealed by the use of cell growth curves, and light- and scanning electron microscopic examinations are also described.
犬尿喹啉酸是一种内源性色氨酸代谢产物，在某些情况下，它可能会在人体组织中蓄积。在早期研究中，犬尿喹啉酸显示出显著的光溶血能力，并且已有确凿证据表明该反应是由单线态氧介导的。本研究的目的是获取更多关于犬尿喹啉酸诱导的光氧化损伤所涉及的细胞机制的信息。本文主要关注利用体外培养细胞建立合适的实验模型，但也描述了通过细胞生长曲线以及光镜和扫描电镜检查所揭示的基础细胞毒性作用。
