早产和足月婴儿首次喂养母乳时的代谢和内分泌事件。
Metabolic and endocrine events at the time of the first feed of human milk in preterm and term infants.
作者信息
Lucas A, Bloom S R, Aynsley-Green A
出版信息
Arch Dis Child. 1978 Sep;53(9):731-6. doi: 10.1136/adc.53.9.731.
Abstract
The first feed of breast milk given to a group of 12 term infants was previously shown to increase the levels of blood glucose and plasma insulin, growth hormone (GH), gastrin, and enteroglucagon. We have now studied the effects of the first feed of breast milk in two similar groups of preterm infants, to compare the results with those obtained for the term infant. One group of 8 preterm infants received a bolus (2.5 ml/kg) of breast milk via a nasogastric tube; the other group of 5 infants received a continuous intragastric infusion (2.5 ml/kg per hour) of breast milk. No change occurred in the concentrations of blood glucose, lactate, pyruvate, or ketone bodies, or in plasma insulin, GH, pancreatic glucagon, or enteroglucagon in either the 'bolus fed' or the 'infusion fed' group of preterm infants. Thus the marked metabolic and endocrine changes in term infants after the first feed do not occur in preterm infants with standard methods of feeding.
摘要
先前的研究表明，给一组12名足月儿首次喂食母乳会使血糖、血浆胰岛素、生长激素（GH）、胃泌素和肠高血糖素水平升高。我们现在研究了首次喂食母乳对两组类似的早产儿的影响，以便将结果与足月儿的结果进行比较。一组8名早产儿通过鼻胃管接受一次推注（2.5毫升/千克）母乳；另一组5名婴儿接受持续胃内输注（每小时2.5毫升/千克）母乳。在“推注喂养”或“输注喂养”的早产儿组中，血糖、乳酸、丙酮酸或酮体的浓度，以及血浆胰岛素、GH、胰高血糖素或肠高血糖素均未发生变化。因此，采用标准喂养方法时，足月儿首次喂食后出现的明显代谢和内分泌变化在早产儿中不会出现。
相似文献
1
Metabolic and endocrine events at the time of the first feed of human milk in preterm and term infants.早产和足月婴儿首次喂养母乳时的代谢和内分泌事件。
Arch Dis Child. 1978 Sep;53(9):731-6. doi: 10.1136/adc.53.9.731.
2
Endocrine and metabolic response in the human newborn to first feed of breast milk.人类新生儿对首次母乳喂养的内分泌和代谢反应。
Arch Dis Child. 1977 Apr;52(4):291-5. doi: 10.1136/adc.52.4.291.
3
Metabolic and endocrine responses to a milk feed in six-day-old term infants: differences between breast and cow's milk formula feeding.六日龄足月儿对一次喂奶的代谢和内分泌反应：母乳喂养与牛乳配方奶喂养的差异。
Acta Paediatr Scand. 1981 Mar;70(2):195-200. doi: 10.1111/j.1651-2227.1981.tb05541.x.
4
Feeding and the development of enteroinsular hormone secretion in the preterm infant: effects of continuous gastric infusions of human milk compared with intermittent boluses.
Acta Paediatr Scand. 1982 May;71(3):379-83. doi: 10.1111/j.1651-2227.1982.tb09438.x.
5
The effect of feeds of differing composition on entero-insular hormone secretion in the first hours of life in human neonates.不同成分的喂养对人类新生儿出生后最初几小时肠胰岛激素分泌的影响。
Acta Paediatr Scand. 1979 Mar;68(2):265-70. doi: 10.1111/j.1651-2227.1979.tb04999.x.
6
Hormonal enteroinsular axis in newborn infants of insulin-treated diabetic mothers.接受胰岛素治疗的糖尿病母亲所生新生儿的激素肠胰岛轴
J Clin Endocrinol Metab. 1993 Nov;77(5):1340-4. doi: 10.1210/jcem.77.5.8077330.
7
Effect of intravenous L-alanine administration on plasma glucose, insulin and glucagon, blood pyruvate, lactate and beta-hydroxybutyrate concentrations in newborn infants. Study in term and preterm newborn infants.
Acta Paediatr Scand. 1978 May;67(3):297-302. doi: 10.1111/j.1651-2227.1978.tb16324.x.
8
Postnatal surges in plasma gut hormones in term and preterm infants.
Biol Neonate. 1982;41(1-2):63-7. doi: 10.1159/000241518.
9
Growth and metabolic and hormonal profiles during transpyloric and nasogastric feeding in preterm infants.
Acta Paediatr Scand. 1981 Jan;70(1):9-13. doi: 10.1111/j.1651-2227.1981.tb07165.x.
10
Fetal and maternal endocrine responses to exercise in the pregnant ewe.怀孕母羊运动时胎儿和母体的内分泌反应。
J Dev Physiol. 1983 Apr;5(2):129-41.
引用本文的文献
1
Insulin resistance prior to term age in very low birthweight infants: a prospective study.早产儿胰岛素抵抗与胎龄的关系：一项前瞻性研究。
BMJ Paediatr Open. 2024 Feb 10;8(1):e002470. doi: 10.1136/bmjpo-2023-002470.
2
Neonatal Hyperglycemia and Neurodevelopmental Outcomes in Preterm Infants: A Review.早产儿的新生儿高血糖与神经发育结局：综述
Children (Basel). 2022 Oct 9;9(10):1541. doi: 10.3390/children9101541.
3
Hyperglycaemia in the Newborn Infant. Physiology Verses Pathology.新生儿高血糖症。生理学与病理学
Front Pediatr. 2021 Jul 21;9:641306. doi: 10.3389/fped.2021.641306. eCollection 2021.
4
Volumetric Analysis of Gallbladder in Extremely Premature Infants.极早产儿胆囊的容积分析
J Med Ultrasound. 2017 Jul-Sep;25(3):138-144. doi: 10.1016/j.jmu.2017.03.004. Epub 2017 Mar 31.
5
Therapeutic insulin and hepatic glucose-6-phosphatase activity in preterm infants.早产婴儿的治疗性胰岛素与肝脏葡萄糖-6-磷酸酶活性
Arch Dis Child Fetal Neonatal Ed. 2000 May;82(3):F228-32. doi: 10.1136/fn.82.3.f228.
6
Development of bowel habit in preterm infants.早产儿排便习惯的发展
Arch Dis Child. 1993 Mar;68(3 Spec No):317-20. doi: 10.1136/adc.68.3_spec_no.317.
7
Gall bladder contractility in preterm infants.早产儿的胆囊收缩功能
Arch Dis Child. 1993 Jan;68(1 Spec No):43-5. doi: 10.1136/adc.68.1_spec_no.43.
8
Gastric ontogeny: clinical implications.胃的个体发生：临床意义。
Arch Dis Child Fetal Neonatal Ed. 1994 Sep;71(2):F136-41. doi: 10.1136/fn.71.2.f136.
9
Plasma motilin, gastrin, and enteroglucagon and feeding in the human newborn.人新生儿的血浆胃动素、胃泌素、肠高血糖素与喂养
Arch Dis Child. 1980 Sep;55(9):673-7. doi: 10.1136/adc.55.9.673.
10
Effects of sleep state and feeding on cranial blood flow of the human neonate.睡眠状态和喂养对人类新生儿颅血流量的影响。
Arch Dis Child. 1980 Apr;55(4):265-70. doi: 10.1136/adc.55.4.265.
本文引用的文献
1
SECRETION AND METABOLISM OF GROWTH HORMONE IN PREMATURE AND FULL-TERM INFANTS.早产儿和足月儿生长激素的分泌与代谢
J Clin Endocrinol Metab. 1965 Feb;25:209-18. doi: 10.1210/jcem-25-2-209.
2
Ketone bodies in the blood of full term newborns, premature and dysmature infants and infants of diabetic mothers.足月新生儿、早产儿、过熟儿及糖尿病母亲所生婴儿血液中的酮体。
Biol Neonat. 1967;11(1):23-8. doi: 10.1159/000240051.
3
The pattern of blood lipids, glycerol and ketone bodies during the neonatal period, infancy and childhood.新生儿期、婴儿期和儿童期血脂、甘油和酮体的模式。
Acta Paediatr Scand. 1966 Jul;55(4):353-62. doi: 10.1111/j.1651-2227.1966.tb08806.x.
4
Changes in the blood levels of acetoacetate and ketone bodies in newborn infants.新生儿血液中乙酰乙酸和酮体水平的变化。
Biol Neonat. 1965;8(5):348-52. doi: 10.1159/000239968.
5
The optimum thermal environment for naked babies.裸身婴儿的最佳热环境。
Arch Dis Child. 1970 Jun;45(241):328-34. doi: 10.1136/adc.45.241.328.
6
The serum insulin and growth hormone response to arginine and to arginine with glucose in the premature infant.早产儿对精氨酸以及精氨酸与葡萄糖联合使用的血清胰岛素和生长激素反应。
J Clin Endocrinol Metab. 1971 Dec;33(6):924-8. doi: 10.1210/jcem-33-6-924.
7
Ketone-body utilization by adult and suckling rat brain in vivo.成年和哺乳大鼠大脑在体内对酮体的利用
Biochem J. 1971 Mar;122(1):13-8. doi: 10.1042/bj1220013.
8
Blood glucose, serum insulin and growth hormone response to intravenous administration of arginine in premature infants.早产儿静脉注射精氨酸后的血糖、血清胰岛素及生长激素反应。
Biol Neonate. 1972;20(3):262-9. doi: 10.1159/000240470.
9
The effects of triglyceride absorption upon glucagon, insulin, and gut glucagon-like immunoreactivity.甘油三酯吸收对胰高血糖素、胰岛素及肠道胰高血糖素样免疫反应性的影响。
J Clin Invest. 1973 Oct;52(10):2532-41. doi: 10.1172/JCI107444.
10
Developmental changes of cerebral ketone body utilization in human infants.
Hoppe Seylers Z Physiol Chem. 1974 Feb;355(2):164-70. doi: 10.1515/bchm2.1974.355.1.164.
Zotero 插件