Buckman K J, Moore S K, Ebbin A J, Cox M B, Dubois E L
Arch Intern Med. 1978 Nov;138(11):1674-6.
Pedigrees were obtained from 340 patients with systemic lupus erythematosus (SLE). Two hundred ten (62%) of the patients were from the wards of Lupus Clinic at the Los Angeles County-University of Southern California Medical Center, and 130 (38%) were from a private practice. Forty-one (12%) of the 340 patients with SLE had affected relatives: five had two and 36 had one affected relative. Ten (30%) of the 33 male patients and 31 (10%) of the 307 female patients had relatives with SLE. Examination of the individual pedigrees included examples of possible autosomal dominant, autosomal recessive, and sex-linked dominant and recessive inheritance. When all the pedigrees were considered as a group, multifactorial inheritance was suggested.
我们获取了340例系统性红斑狼疮（SLE）患者的家系。其中210例（62%）患者来自洛杉矶县南加州大学医学中心狼疮诊所病房，130例（38%）来自私人诊所。340例SLE患者中有41例（12%）有患病亲属：5例有两个患病亲属，36例有一个患病亲属。33例男性患者中有10例（30%）、307例女性患者中有31例（10%）有患SLE的亲属。对各个家系的检查包括可能的常染色体显性、常染色体隐性、性连锁显性和隐性遗传的实例。当将所有家系作为一个整体考虑时，提示为多因素遗传。
