Xu S B, Huang Y M, Lau C N, Wat C K, Kong Y C
Am J Chin Med. 1982;10(1-4):75-85. doi: 10.1142/S0192415X82000130.
Dehydroevodiamine isolated from Evodiae Fructus lowered blood pressure with bradycardia in anesthetised rats. At a cumulative dose of 22.5mg/kg/30min, there was a very significant decrease in blood pressure and heart rate. There was a more important decrease in diastolic pressure than systolic pressure, implying a vasodilatory effect. The hypotensive effect of dehydroevodiamine can be abolished partly by indomethacin and more completely, polyphoretin phosphate. It is suggested that the hypotensive effect of dehydroevodiamine may be mediated through prostaglandin synthesis. A similar action mechanism in dehydroevodiamine-stimulated rat uterus contraction is also discussed.
从吴茱萸中分离出的去氢吴茱萸碱可使麻醉大鼠血压降低并伴有心动过缓。在累积剂量为22.5mg/kg/30min时，血压和心率有非常显著的下降。舒张压的下降比收缩压更明显，这意味着有血管舒张作用。消炎痛可部分消除去氢吴茱萸碱的降压作用，而磷酸多果定则可更完全地消除其降压作用。提示去氢吴茱萸碱的降压作用可能是通过前列腺素合成介导的。还讨论了去氢吴茱萸碱刺激大鼠子宫收缩的类似作用机制。
