Yang M C, Wu S L, Kuo J S, Chen C F
Department of Medical Research, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Eur J Pharmacol. 1990 Jul 17;182(3):537-42. doi: 10.1016/0014-2999(90)90052-8.
The cardiovascular effects of dehydroevodiamine, an alkaloid isolated from Evodia rutaecarpa Jussieu, were studied in both in vivo and in vitro experiments. The in vivo experiments revealed that i.v. administration of dehydroevodiamine elicited a slight but significant reduction in blood pressure and a marked decrease in heart rate which was confirmed by an increased cycle length of the electrocardiogram. However, a hemodynamic experiment with microspheres showed that the total peripheral resistance was not altered by dehydroevodiamine. The blood flows of various organs were not significantly changed except those of kidney and skin, in which blood flow was decreased. In vitro, the spontaneously beating atria were significantly suppressed by dehydroevodiamine in a dose-dependent manner. These findings suggested an important effect of dehydroevodiamine in suppressing the heart, which may largely contribute to the hypotensive effect of this alkaloid. However, its vasodilator effect on hindquarter muscles cannot be neglected.
对从吴茱萸中分离出的一种生物碱——吴茱萸次碱的心血管作用进行了体内和体外实验研究。体内实验表明，静脉注射吴茱萸次碱会引起血压轻微但显著降低，心率明显下降，心电图周期长度增加证实了这一点。然而，用微球进行的血流动力学实验表明，吴茱萸次碱不会改变总外周阻力。除肾脏和皮肤外，各器官的血流量没有显著变化，肾脏和皮肤的血流量减少。在体外，吴茱萸次碱以剂量依赖的方式显著抑制自发跳动的心房。这些发现表明吴茱萸次碱在抑制心脏方面具有重要作用，这可能在很大程度上导致了这种生物碱的降压作用。然而，其对后肢肌肉的血管舒张作用也不容忽视。
