Syndulko K, Cohen S N, Tourtellotte W W, Potvin A R
Bull Los Angeles Neurol Soc. 1982;47:124-40.
The primary neurologic application of event-related potentials (ERP) to date has been of relatively short-latency (less than 100-200 ms), stimulus-dependent components. These so-called exogenous components are used to evaluate the structural, and to a lesser extent, the functional integrity of primary afferent pathways. Another class of ERP, termed endogenous, and involving longer-latency (greater than 100 ms) stimulus-independent components has been utilized by psychologists and cognitive psychophysiologists in the measuring of neurocognitive processes. Although the experimental specification of these neurocognitial processes is still in its infancy, the empirical applications of endogenous ERP's offers considerable promise for objective non-invasive evaluations of cognitive functions now conducted only behaviorally. Initial neurocognitive ERP applications have focused on global mental status in dementia. A brief review is presented of experimental studies of some endogenous ERPs (mainly P300), their hypothesized underlying neurocognitive processes, and initial and potential clinical applications.
迄今为止，事件相关电位（ERP）在神经学方面的主要应用是针对潜伏期相对较短（小于100 - 200毫秒）、依赖刺激的成分。这些所谓的外源性成分用于评估初级传入通路的结构完整性，在较小程度上也用于评估其功能完整性。另一类ERP，称为内源性ERP，涉及潜伏期较长（大于100毫秒）且与刺激无关的成分，心理学家和认知心理生理学家已将其用于测量神经认知过程。尽管这些神经认知过程的实验规范仍处于起步阶段，但内源性ERP的实证应用为目前仅通过行为方式进行的认知功能客观无创评估提供了相当大的前景。最初的神经认知ERP应用集中于痴呆症患者的整体精神状态。本文简要综述了一些内源性ERP（主要是P300）的实验研究、其假定的潜在神经认知过程以及最初的和潜在的临床应用。
