Halgren E, Squires N K, Wilson C L, Crandall P H
Bull Los Angeles Neurol Soc. 1982;47:108-23.
Locating the synapses which generate endogenous potential components recorded at the scalp would permit some aspects of the neural activity directly underlying cognition to be probed non-invasively. Knowing which synapses are functioning abnormally in certain neurological and psychiatric diseases may suggest rational treatment strategies aimed at local brain regions. Although it is not possible to localize the generating synapses using scalp topography, large potentials can be recorded in the hippocampal formation during the same task conditions which evoke scalp endogenous potentials. Phase-reversal of these hippocampal potentials over short distances, accompanied by changes in simultaneously recorded unit-activity, indicates that they are generated locally. Demonstration that they volume-conduct to the scalp would, however, require observation of lesion effects, and recordings from other candidate structures, as well as a realistic model for propagation.
确定在头皮记录到的内源性电位成分所产生的突触，将能够以非侵入性方式探究认知直接背后的神经活动的某些方面。了解在某些神经和精神疾病中哪些突触功能异常，可能会提示针对局部脑区的合理治疗策略。尽管利用头皮地形图无法定位产生电位的突触，但在诱发头皮内源性电位的相同任务条件下，海马结构中可记录到较大电位。这些海马电位在短距离内的相位反转，伴随着同时记录的单位活动的变化，表明它们是在局部产生的。然而，要证明它们通过容积传导至头皮，需要观察病变效应、从其他候选结构进行记录以及一个现实的传播模型。
