紫外线照射细胞核中DNA-组蛋白交联的机制。
Mechanism of DNA-histone crosslinks in UV-irradiated nuclei.
作者信息
Saito I, Sugiyama H, Matsuura T
出版信息
Nucleic Acids Symp Ser. 1982(11):225-8.
PMID:7183962
Abstract
Mechanism of the DNA-histone crosslinks in UV-irradiated chicken erythrocyte nuclei has been investigated. It has been demonstrated that the major chemical reaction induced by irradiation of DNA-histone complexes is the crosslinking between lysine and thymine residues and subsequent transfer of thyminyl group from DNA to lysine residues of histones.
摘要
对紫外线照射的鸡红细胞核中DNA-组蛋白交联的机制进行了研究。结果表明，DNA-组蛋白复合物受照射诱导的主要化学反应是赖氨酸与胸腺嘧啶残基之间的交联，以及随后胸腺嘧啶基团从DNA转移至组蛋白的赖氨酸残基上。
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