Jakab L, Pozsonyi T, Fehér J
Acta Med Acad Sci Hung. 1976;33(2):161-9.
The concentration of IgA, IgG, IgM, coeruloplasmin, alpha-2-macroglobulin, beta-1-C-globulin, transferrin as well as of alpha-2-haptoglobin, orosomucoid and haemopexin has been studied in the serum of patients with disseminated lupus erythematosus, chronic progressive polyarthritis and immunopathological syndromes. The concentration of the carbohydrate components bound to serum proteins was also determined. In disseminated lupus erythematosus, the concentration of IgA, IgG, IgM, coeruloplasmin, and hexose, hexosamine and sialic acid bound to proteins, as well as of seromucoid was increased. In chronic progressive polyarthritis the IgA, IgG, IgM, coeruloplasmin, alpha-2-macroglobulin and beta-1-C-globulin concentration and the carbohydrate components bound to serum proteins rose. In immunopathological syndromes, too, the serum IgA, IgG, IgM, coeruloplasmin, and protein-bound hexosamine and sialic acid levels were increased. Under the effect of treatment, the elevated glycoprotein concentrations usually decrease, but the level of carbohydrate components bound to serum proteins hardly changes. The pathogenic and diagnostic significance of serum glycoproteins is discussed.
对患有播散性红斑狼疮、慢性进行性多关节炎和免疫病理综合征患者的血清中免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、免疫球蛋白M（IgM）、铜蓝蛋白、α2-巨球蛋白、β1-C球蛋白、转铁蛋白以及α2-触珠蛋白、血清类粘蛋白和血红素结合蛋白的浓度进行了研究。还测定了与血清蛋白结合的碳水化合物成分的浓度。在播散性红斑狼疮中，IgA、IgG、IgM、铜蓝蛋白以及与蛋白质结合的己糖、己糖胺和唾液酸以及血清类粘蛋白的浓度升高。在慢性进行性多关节炎中，IgA、IgG、IgM、铜蓝蛋白、α2-巨球蛋白和β1-C球蛋白浓度以及与血清蛋白结合的碳水化合物成分升高。在免疫病理综合征中，血清IgA、IgG、IgM、铜蓝蛋白以及与蛋白质结合的己糖胺和唾液酸水平也升高。在治疗作用下，升高的糖蛋白浓度通常会降低，但与血清蛋白结合的碳水化合物成分水平几乎不变。讨论了血清糖蛋白的致病和诊断意义。
