Fehér J, Jakab L, Pozsonyi T, Gráf F
Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(3):326-37.
In the serum of 27 patients with malignant lymphogranulomatosis the authors determined the serum level of glycoproteid-carbohydrate components (hexose, hexosamine, sialin acid, and seromucoid) and the concentration of 11 different glycoproteids. In the early stage of the disease the immunoglobulin level is moderately increased in the serum, whereas a diminution can be observed in stage IV. The concentrations of ceruloplasmin, alpha-2-macroglobulin and orosomucoid were already increased significantly in stage III. The increase did not continue in stage IV. In the final stage of the disease the concentrations of alpha-1-antitrypsin and haemopexin turned out to be increased considerably. A significant decrease in the transferrin level could be registered in stage III with this diminution also continuing in the further course. Changes of beta-C-globulin and haptoglobin concentrations could not be evaluated statistically. The content of carbohydrate components in the glycoproteids will already increase in the early stage of the disease with this increase continuing in the further course. Among histological types there was a more significant increase of immunoglobulins in those forms rich of lymphocytes.
作者测定了27例恶性淋巴肉芽肿病患者血清中糖蛋白碳水化合物成分（己糖、己糖胺、唾液酸和血清类粘蛋白）的水平以及11种不同糖蛋白的浓度。在疾病早期，血清中免疫球蛋白水平适度升高，而在IV期可观察到降低。在III期，铜蓝蛋白、α-2-巨球蛋白和血清类粘蛋白的浓度已显著升高。在IV期这种升高没有持续。在疾病终末期，α-1-抗胰蛋白酶和血红素结合蛋白的浓度大幅升高。在III期可记录到转铁蛋白水平显著降低，且在病程中这种降低持续存在。β-C球蛋白和触珠蛋白浓度的变化无法进行统计学评估。糖蛋白中碳水化合物成分的含量在疾病早期就已增加，且在病程中持续增加。在组织学类型中，富含淋巴细胞的类型中免疫球蛋白的增加更为显著。
