Markiewicz K, Lukin M, Jazdzewski B, Cholewa M
Acta Physiol Pol. 1982 Jul-Aug;33(4):295-304.
The purpose of this work was determination of furosemide effect on basal gastric secretion during exercise and postexercise restitution in 8 healthy men aged 22-25 years. The investigations were performed three times determining each time the basal acid output during three successive hours. In the first test the determinations were done during one hour rest, then after intravenous furosemide administration 2 mg/kg, and again between 60 and 120 minutes after the injection. In the second test BAO was determined at rest, during one-hour exercise, and during restitution. In the third test the determinations were done at rest, during exercise preceded by furosemide injection as in the first test, and during one hour of post-exercise restitution. The exercise on a Monark cycle ergometer was, on the average, 275 210 +/- 12 500 J in the second test and 284 870 +/- 14 480 J in the third test. Furosemide caused a statistically significant decrease of BAO at rest (p less than 0.02) and during exercise (p less than 0.01), this was due to a significant reduction in gastric juice volume (p less than 0.001) and in the second hour of furosemide action also to a decrease of HCI concentration (p less than 0.05). Decreased excretion of electrolytes by the gastric mucosa was proportional to changes in gastric juice volume. The 24-hour urinary excretion of sodium, potassium and chlorides increased after furosemide in the first test (p less than 0.001), and in the third test (p less than 0.02).
这项研究的目的是确定速尿对8名年龄在22至25岁的健康男性运动期间及运动后恢复过程中基础胃酸分泌的影响。研究分三次进行，每次连续三小时测定基础酸排出量。在第一次测试中，先在一小时休息期间进行测定，然后静脉注射速尿2mg/kg，注射后60至120分钟再次测定。在第二次测试中，分别在休息时、一小时运动期间及恢复过程中测定基础酸排出量。在第三次测试中，同样先在休息时进行测定，然后如第一次测试那样在注射速尿后进行运动，并在运动后一小时恢复过程中进行测定。在第二次测试中，使用莫纳克自行车测力计进行的运动平均为275210±12500焦耳，在第三次测试中为284870±14480焦耳。速尿导致休息时（p＜0.02）和运动期间（p＜0.01）基础酸排出量出现统计学显著下降，这是由于胃液量显著减少（p＜0.001），且在速尿作用的第二小时，盐酸浓度也降低（p＜0.05）。胃黏膜电解质排泄减少与胃液量变化成比例。在第一次测试（p＜0.001）和第三次测试（p＜0.02）中，速尿后24小时尿钠、钾和氯的排泄量增加。
