Wróblewski T, Witanowska A
Acta Physiol Pol. 1982 Jul-Aug;33(4):353-60.
In order to explain whether the arterial smooth muscle exhibits altered contractile properties in atherosclerosis, normal and atherosclerotic rabbit aortic strips were exposed to noradrenaline (NA) and potassium chloride (KCl). The experiments were repeated with normal blood and the containing an excess of free fatty acids (FFA) added to the bath. Contraction induced by NA was markedly enhanced in the atherosclerotic trips. In contrast the response of atherosclerotic aorta strips to KCl was reduced. Excess FFA blood added to the bath with NA normalized the previously enhanced contractile response in atherosclerotic aortic strips. An opposite change in KCl induced contraction was observed under the some conditions namely increased response occurred. We conclude that the enhanced reaction of atherosclerotic aortic strips to NA depending on a specific mechanism might be reversed by elevation of FFA in blood.
为了解释动脉平滑肌在动脉粥样硬化中是否表现出收缩特性改变，将正常和动脉粥样硬化兔主动脉条暴露于去甲肾上腺素（NA）和氯化钾（KCl）中。实验用正常血液重复进行，并向浴槽中添加过量游离脂肪酸（FFA）。NA诱导的收缩在动脉粥样硬化条带中明显增强。相反，动脉粥样硬化主动脉条带对KCl的反应减弱。向含有NA的浴槽中添加过量FFA血液可使动脉粥样硬化主动脉条带先前增强的收缩反应恢复正常。在相同条件下观察到KCl诱导收缩的相反变化，即反应增强。我们得出结论，动脉粥样硬化主动脉条带对NA的增强反应可能取决于一种特定机制，血液中FFA升高可使其逆转。
