[有机硅化合物的抗肿瘤作用（IV）。SDK - 50和SDK - 47的抗肿瘤作用]
[Antitumor effects of organic silicone compounds (IV). Antitumor effects of SDK-50 and SDK-47].
作者信息
Toyoshima S, Fukushima K, Sakurai T, Sugimoto Y, Sato H, Taguchi H
出版信息
Gan To Kagaku Ryoho. 1982 Feb;9(2):225-9.
From the results of the 1st and 2nd screening as to the antitumor effect of organosilica compounds, two compounds, namely, SDK-50 (2-piperidinoethyl-phenyldimethyl-silane) and SDK-47 (3-N-2-propenylamino) propyltrimethyl-silane were selected. These two compounds were further tested by using the solid form cancer of Ehrlich, sarcoma-180 and Lewis lung carcinoma in mice and moreover the rats bearing ascites hepatomas. AH-13, 130, 272, 44, 66F, 66, 7974, 41-C, 60-C and 109A. From the summarized data, it may be said that the effect of SDK-50 is relatively superior to SDK-47. In addition of the inhibitory effect on cancer cells, it was found that SDK-50 possesses an activating effect of delayed type hypersensitivity. This effect of SDK-50 was equivalent to PSK or SPG.
根据第一次和第二次筛选有机硅化合物抗肿瘤效果的结果，挑选出了两种化合物，即SDK - 50（2 - 哌啶基乙基 - 苯基二甲基硅烷）和SDK - 47（3 - N - 2 - 丙烯基氨基）丙基三甲基硅烷。使用小鼠体内的艾氏实体癌、肉瘤 - 180和刘易斯肺癌，以及携带腹水肝癌的大鼠（AH - 13、130、272、44、66F、66、7974、41 - C、60 - C和109A）对这两种化合物进行了进一步测试。从汇总数据来看，可以说SDK - 50的效果相对优于SDK - 47。除了对癌细胞的抑制作用外，还发现SDK - 50具有迟发型超敏反应的激活作用。SDK - 50的这种作用与PSK或SPG相当。
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