Hayakawa M, Sakuma A, Oouchi A, Takahashi M, Satoh T
Gan To Kagaku Ryoho. 1982 Apr;9(4):660-6.
Suppository of 5-Fluorouracil (5-FU) was administered preoperatively to 19 patients with rectal cancer. In the bioassay of 5-FU concentration in the rectal specimens, 5-FU was detected in the wall distant more than 20 cm from the anal ring, in the lymph nodes and in the blood of superior rectal vein. Ten of 19 cases were treated with suppository and 5-FU solution by intravenous injection at the same time, and the other 9 cases with suppository only. In the former group, 6 cases improved remarkably, and 3 cases in the latter group. Remarkable anticancer effect of 5-FU suppository was found in 9 of total 19 cases. Accordingly, it was suggested that the combination use of than suppository alone suppository and the systemic administration of 5-FU was more effective in cancer chemotherapy.
对19例直肠癌患者术前给予5-氟尿嘧啶（5-FU）栓剂。在对直肠标本中5-FU浓度的生物测定中，在距肛环20cm以上的肠壁、淋巴结及直肠上静脉血中均检测到5-FU。19例患者中，10例同时接受栓剂和5-FU溶液静脉注射治疗，另外9例仅接受栓剂治疗。前一组中6例改善明显，后一组中3例改善明显。19例患者中共有9例显示5-FU栓剂有显著抗癌效果。因此，提示5-FU栓剂与全身给药联合使用比单独使用栓剂在癌症化疗中更有效。
