Markesbery W R, Brooks W H, Gupta G D, Young A B
Arch Neurol. 1978 Nov;35(11):754-6. doi: 10.1001/archneur.1978.00500350058012.
To establish the effectiveness of treatment of patients with intracranial metastatic neoplasms, a retrospective study of survival of patients who had surgical excision, irradiation, or chemotherapy was compared with survival of patients who received no treatment. Our results indicate that although any form of therapy was superior to no treatment, no modality was clearly better than another. Furthermore, the prognosis for survival of patients with solitary lesions from a known primary was only slightly better than that of patients with numerous metastases. The prognosis was slightly improved when the cerebral lesion was detected before finding the primary site of origin. These observations should be considered when planning treatment for patients with brain metastases.
为确定颅内转移性肿瘤患者的治疗效果，对接受手术切除、放疗或化疗患者的生存率进行了一项回顾性研究，并与未接受治疗患者的生存率进行了比较。我们的结果表明，尽管任何形式的治疗都优于不治疗，但没有一种治疗方式明显优于另一种。此外，已知原发灶的孤立性病变患者的生存预后仅略好于有多处转移的患者。当在发现原发灶之前检测到脑部病变时，预后略有改善。在为脑转移患者制定治疗计划时，应考虑这些观察结果。
