Gundersen T, Smith T R, Zakov N, Albert D M
Arch Ophthalmol. 1978 Nov;96(11):2089-92. doi: 10.1001/archopht.1978.03910060469017.
A pigmented choroidal lesion was observed 41 years prior to enucleation. The patient, with a clinical diagnosis of malignant melanoma in an eye with good visual function, was followed up for the last 25 years by one of the authors. Sudden growth of the lesion and loss of vision led to enucleation and allowed histologic confirmation of the diagnosis of malignant melanoma. A pigmented iris lesion in the same eye was also present for 25 years and showed no notable growth under observation. The patient died of metastatic disease approximately one year after enucleation.
眼球摘除术前41年观察到脉络膜色素沉着病变。该患者临床诊断为视力良好的眼内恶性黑色素瘤，由本文作者之一随访了25年。病变突然生长并导致视力丧失，随后进行了眼球摘除术，组织学检查确诊为恶性黑色素瘤。同一只眼的虹膜色素沉着病变也已存在25年，观察期间未见明显生长。患者在眼球摘除术后约一年死于转移性疾病。
