Maggi R, Jasinski C, Balás R, Martinotti M, Crespo J, Paciel J, Galbarin E
Arq Gastroenterol. 1982 Apr-Jun;19(2):87-90.
Since the description of the association of HLA-B8 antigen with celiac disease, it has been confirmed by many authors. The incidence of HLA-B8 antigen is higher in adults and children when it is compared to apparently healthy controls. Some authors found a reduction on the incidence of HLA-B7 antigen and others suggested that a higher incidence of HLA-B12 antigen in patients HLA-B8 antigen negative, is associated with celiac disease. We studied 19 unrelated patients with celiac disease and 64 controls. Their ages range from 18 months to 18 years old, onset of the disease was during childhood. We determined twelve antigens of the HLA-A locus and thirteen antigens of the HLA-B locus. We used the NIH Microlymphocytotoxicity Technique. The degree of association was computed by the relative risk and the results were statistically evaluated by the X2. The statistically significant increase in frequency was shown only for HLA-A29 The results did not show neither the higher incidence for HLA-B8 found by other authors, nor the higher incidence for HLA-B12; however HLA-B7 was not detected in our patients. The final decision on the association of HLA-A29 antigen with celiac disease in our population will require examination of a broader panel of probands.
自从描述了HLA - B8抗原与乳糜泻的关联以来，许多作者都证实了这一点。与明显健康的对照组相比，HLA - B8抗原在成人和儿童中的发生率更高。一些作者发现HLA - B7抗原的发生率有所降低，而其他作者则认为，在HLA - B8抗原阴性的患者中，HLA - B12抗原的较高发生率与乳糜泻有关。我们研究了19例无亲缘关系的乳糜泻患者和64例对照。他们的年龄从18个月到18岁不等，疾病发病于儿童期。我们测定了HLA - A位点的12种抗原和HLA - B位点的13种抗原。我们使用了美国国立卫生研究院的微量淋巴细胞毒性技术。关联程度通过相对风险计算，结果通过X2进行统计学评估。仅HLA - A29显示出频率有统计学意义的增加。结果既未显示出其他作者所发现的HLA - B8的较高发生率，也未显示出HLA - B12的较高发生率；然而，我们的患者中未检测到HLA - B7。关于HLA - A29抗原与我们人群中乳糜泻的关联的最终结论将需要对更广泛的先证者群体进行检查。
