Erkan T, Kutlu T, Yilmaz E, Cullu F, Tümay G T
Department of Pediatrics, Istanbul University Cerrahpaşa Faculty of Medicine.
Turk J Pediatr. 1999 Apr-Jun;41(2):181-8.
With the aim to determine the frequency of human leukocyte antigen phenotypes of celiac disease in Turkey, thirty celiac patients fulfilling the European Society of Pediatric Gastroenterology and Nutrition criteria were included in the study. The mean age of the study population was 5.8 +/- 4.3 years and of the control subjects was 32.6 +/- 6.7 years. The human leukocyte antigens -A, -B, -DR and -DQ were studied serologically by micro lymphocytotoxic reaction. It was found that human leukocyte antigens A-25(10), -B8, -DR18(3) and -DQ2 were more significantly frequent in the celiac population than in the control group. Children with antigen -B8 showed a five times higher risk for celiac disease and those with antigen -DQ2 showed a nine times higher risk. It was determined that human leukocyte antigen -B4 had a protective role in celiac disease. The study suggests that the human leukocyte antigen -A25(10) is a phenotype particularly encountered in Turkish pediatric celiac patients.
为了确定土耳其乳糜泻患者人类白细胞抗原表型的频率，本研究纳入了30名符合欧洲儿科胃肠病学和营养学会标准的乳糜泻患者。研究人群的平均年龄为5.8±4.3岁，对照组的平均年龄为32.6±6.7岁。通过微量淋巴细胞毒反应对人类白细胞抗原-A、-B、-DR和-DQ进行血清学研究。结果发现，乳糜泻患者人群中人类白细胞抗原A-25(10)、-B8、-DR18(3)和-DQ2的出现频率明显高于对照组。携带抗原-B8的儿童患乳糜泻的风险高出五倍，携带抗原-DQ2的儿童患乳糜泻的风险高出九倍。研究确定人类白细胞抗原-B4在乳糜泻中具有保护作用。该研究表明，人类白细胞抗原-A25(10)是土耳其儿科乳糜泻患者中特别常见的一种表型。
