Kodera K, Yamada O, Yamane H, Suzuki J I
Audiology. 1978 Nov-Dec;17(6):500-10. doi: 10.3109/00206097809072610.
Effects of stimulus number and interstimulus interval on auditory-evoked fast responses (BSR: Jewett's V, and middle-latency components: Na, Pa and Nb) were studied by using 1000- and 500-Hz tone pips in 6 normal human adults. At a stimulus intensity of 50 dB SL, 500 stimuli evoked BSRs and the middle-latency components in all cases. At a stimulus intensity of 30 dB SL, 1000 stimuli were necessary to evoke BSRs and Na in all 6 subjects. Even 4000 stimuli were not sufficient for identifying Pa in 1 subject and Nb in 3 subjects. The largest mean peak-to-peak amplitude was the Na-Pa amplitude, but, differences across subjects were large. On the other hand, the BSR-Na amplitude showed relatively small differences across subjects. The BSR latencies were highly stable across subjects. These characteristics indicate that the BSR-Na component is more suitable as an indicator for objective audiometry than either the Na-Pa or Pa-Nb component. The BSR-Na amplitude did not show a decrease as the interstimulus interval was decreased from 104 to 32 ms. On the other hand, the Na-Pa amplitude significantly decreased as the interstimulus interval was decreased from 104 to 42 ms, and the Pa-Nb amplitude also significantly decreased as the interstimulus interval was decreased from 104 to 73 ms. Therefore, because of its resistance to the effects of high rates of stimulation, the BSR-Na component appears to be a suitable audiometric index in the clinical situation where time constraints are a consideration.
采用1000Hz和500Hz的短纯音，对6名正常成年人进行研究，观察刺激次数和刺激间隔对听觉诱发快速反应（脑干反应：朱厄特氏V波，以及中潜伏期成分：Na波、Pa波和Nb波）的影响。在50dB SL的刺激强度下，500次刺激在所有情况下均能诱发出脑干反应和中潜伏期成分。在30dB SL的刺激强度下，6名受试者均需要1000次刺激才能诱发出脑干反应和Na波。甚至4000次刺激也不足以使1名受试者识别出Pa波，3名受试者识别出Nb波。最大的平均峰峰值幅度是Na波-Pa波幅度，但个体间差异较大。另一方面，脑干反应-Na波幅度在个体间的差异相对较小。脑干反应的潜伏期在个体间高度稳定。这些特征表明，与Na波-Pa波或Pa波-Nb波成分相比，脑干反应-Na波成分更适合作为客观听力测定的指标。当刺激间隔从104ms缩短至32ms时，脑干反应-Na波幅度并未降低。另一方面，当刺激间隔从104ms缩短至42ms时，Na波-Pa波幅度显著降低，当刺激间隔从104ms缩短至73ms时，Pa波-Nb波幅度也显著降低。因此，由于其对高刺激率影响的抵抗力，在需要考虑时间限制的临床情况下，脑干反应-Na波成分似乎是一个合适的听力测定指标。
