Heck H D
Fundam Appl Toxicol. 1981 Jul-Aug;1(4):299-308. doi: 10.1016/s0272-0590(81)80036-x.
The induction of calcium terephthalate (CaTPA) calculi in the urinary tract of rats ingesting terephthalic acid (TPA) or dimethyl terephthalate is a result of supersaturation with respect to the stone components. The solubility product of CaTPA was determined in water at 37 degrees C, and its value in urine of exposed weanling Fischer-344 rats was calculated based on the electrolyte concentrations of freshly-collected, microliter urine samples. The value of the solubility product in urine is equal to the minimum concentration product of free Ca2+ and TPA2- at which crystallization can occur; hence, the urinary solubility product is a parameter that is useful for risk assessment. Estimates of the TPA concentrations required to induce crystals or stones in normal human urine are presented.
在摄入对苯二甲酸（TPA）或对苯二甲酸二甲酯的大鼠尿路中诱导生成对苯二甲酸钙（CaTPA）结石，是结石成分过饱和的结果。在37℃的水中测定了CaTPA的溶度积，并根据新鲜采集的微升尿液样本的电解质浓度，计算了暴露的断乳Fischer-344大鼠尿液中的溶度积值。尿液中溶度积的值等于能够发生结晶的游离Ca2+和TPA2-的最低浓度积；因此，尿液溶度积是一个有助于风险评估的参数。文中给出了在正常人类尿液中诱导形成晶体或结石所需的TPA浓度估计值。
