Zelenak J P, Alarie Y, Weyel D A
Fundam Appl Toxicol. 1982 Jul-Aug;2(4):177-80. doi: 10.1016/s0272-0590(82)80043-2.
Guinea pigs were exposed for thirty minutes to a particulate aerosol of sodium lauryl sulfate at concentrations of 17.3, 28.9 and 48.6 mg/m3. The exposure chamber in which individual guinea pigs were exposed was fitted with a microphone to record coughing. As the concentration of sodium lauryl sulfate increased, the combined number and severity of the coughs increased and a fade in the response was also observed with exposure duration. Citric acid, a tussigenic agent commonly used to test antitussive agents was also tested using the same experimental protocol and was found to be about an order of magnitude less potent than sodium lauryl sulfate. This model could be useful in assessing the irritating properties of various aerosols to the tracheo-bronchial tree.
将豚鼠暴露于浓度为17.3、28.9和48.6毫克/立方米的月桂醇硫酸酯钠颗粒气溶胶中30分钟。暴露单个豚鼠的暴露室装有麦克风以记录咳嗽。随着月桂醇硫酸酯钠浓度的增加，咳嗽的次数和严重程度均增加，并且随着暴露时间的延长还观察到反应减弱。柠檬酸是一种常用于测试镇咳药的致咳剂，也使用相同的实验方案进行了测试，发现其效力比月桂醇硫酸酯钠低约一个数量级。该模型可用于评估各种气溶胶对气管支气管树的刺激特性。
