John J A, Murray F J, Quast J F, Keeler P A, Schwetz B A, Staples R E
Fundam Appl Toxicol. 1982 Sep-Oct;2(5):220-5. doi: 10.1016/s0272-0590(82)80030-4.
The teratogenicity of tetrachloroacetone (TCA) was evaluated in CF-1 mice and New Zealand white rabbits. Mice were given 0, 5, 15 or 50 mg/kg/day of TCA by gavage on days 6 through 15 of gestation. Rabbits were given 0, 1, 5, or 10 mg/kg/day on days 6 through 18 of gestation. The incidence of malformed fetuses was not significantly increased among mice given 5, 15 or 50 mg/kg/day of TCA. Sixteen fetuses in 3 litters in the 50 mg/kg/day group had cleft palate; they were from three dams which showed the most severe signs of toxicity, including depressed weight gain, decreased water consumption, and gastric ulceration. Dosage with 5 mg/kg/day, a level which was not toxic to the pregnant female, was not toxic to developing mouse fetuses. Fetal effects in rabbits were limited to a slight, but not statistically significant or dose related increase in the incidence of malformed fetuses. On the basis of these results, TCA does not appear to represent a unique hazard to the conceptus.
在CF-1小鼠和新西兰白兔中评估了四氯丙酮（TCA）的致畸性。在妊娠第6至15天，通过灌胃给予小鼠0、5、15或50 mg/kg/天的TCA。在妊娠第6至18天，给予兔子0、1、5或10 mg/kg/天的TCA。给予5、15或50 mg/kg/天TCA的小鼠中，畸形胎儿的发生率没有显著增加。在50 mg/kg/天组的3窝中有16只胎儿出现腭裂；它们来自三只母鼠，这三只母鼠表现出最严重的毒性迹象，包括体重增加受抑制、饮水量减少和胃溃疡。5 mg/kg/天的剂量对怀孕母鼠无毒，对发育中的小鼠胎儿也无毒。兔子的胎儿效应仅限于畸形胎儿发生率略有增加，但无统计学意义且与剂量无关。基于这些结果，TCA似乎对胎儿不构成独特的危害。
