Berdasco N M, Lomax L G, Zimmer M A, Hanley T R
Mammalian and Environmental Toxicology Research Laboratory, Dow Chemical Company, Midland, Michigan 48674.
Fundam Appl Toxicol. 1988 Oct;11(3):464-71. doi: 10.1016/0272-0590(88)90110-8.
Pregnant Fischer 344 rats and New Zealand White rabbits were orally administered 0, 5, 15, or 50 mg nitrapyrin/kg/day on Gestation Days 6 through 15 (rats) or 0, 3, 10, or 30 mg/kg/day on Gestation Days 6 through 18 (rabbits). In rats, 50 mg/kg/day produced slight histopathologic changes in the livers of pregnant females. Fetal examination revealed no evidence of fetotoxicity or teratogenicity among rats at dose levels up to 50 mg/kg/day. Among rabbits, a significant depression in maternal weight gain and increased absolute and relative liver weights were observed at 30 mg/kg/day. An increased incidence of crooked hyoid bone among fetal rabbits in the 30 mg/kg/day dose group was considered indicative of fetotoxicity but not teratogenicity. Thus, administration of nitrapyrin was not teratogenic at dose levels up to 50 mg/kg/day in rats and 30 mg/kg/day in rabbits.
在妊娠第6至15天（大鼠），给怀孕的Fischer 344大鼠口服0、5、15或50毫克硝吡啉/千克/天，或在妊娠第6至18天（兔子）口服0、3、10或30毫克/千克/天。在大鼠中，50毫克/千克/天使怀孕雌性大鼠的肝脏出现轻微组织病理学变化。胎儿检查显示，在剂量高达50毫克/千克/天的大鼠中，没有胎儿毒性或致畸性的证据。在兔子中，在30毫克/千克/天的剂量下，观察到母体体重增加显著下降，肝脏绝对重量和相对重量增加。在30毫克/千克/天剂量组的胎兔中，舌骨弯曲的发生率增加被认为表明有胎儿毒性，但没有致畸性。因此，在大鼠中剂量高达50毫克/千克/天和兔子中剂量高达30毫克/千克/天时，硝吡啉给药没有致畸性。
