Sieklucka-Dziuba M, Kleinrok Z
Acta Physiol Pol. 1982 Sep-Dec;33(5-6):567-75.
In the experiments on Wistar rats it was demonstrated that pilocarpine and physostigmine decreased the GABA level in the striatum. This change was prevented by atropine. Lobeline and nicotine exerted a biphasic effect on GABA level: given in small doses 15 min before decapitation they raised, and in higher doses they decreased this level. This was due to their biphasic effect on the cholinergic receptor N. The changes in GABA level produced by stimulation of N receptors by lobeline and nicotine were prevented by mecamylamine and d-tubocurarine, and in part also by atropine and propranolol. This suggests an indirect participation of M and beta receptors in the transmission of impulses from the cholinergic receptors N to the GABA-ergic system. The effect of the tested substances on GAD activity was not uniform. No strict correlation was demonstrated between GAD activity and GABA level.
在对Wistar大鼠的实验中表明，毛果芸香碱和毒扁豆碱可降低纹状体中的γ-氨基丁酸（GABA）水平。这种变化可被阿托品阻止。洛贝林和尼古丁对GABA水平产生双相效应：在断头前15分钟给予小剂量时会使其升高，而给予高剂量时则会使其降低。这是由于它们对胆碱能受体N产生双相效应。洛贝林和尼古丁通过刺激N受体所引起的GABA水平变化可被美加明和d-筒箭毒碱阻止，部分也可被阿托品和普萘洛尔阻止。这表明M受体和β受体间接参与了从胆碱能受体N到GABA能系统的冲动传递。所测试物质对谷氨酸脱羧酶（GAD）活性的影响并不一致。未证明GAD活性与GABA水平之间存在严格的相关性。
