西咪替丁对体外造血的影响。
Effects of cimetidine on haematopoiesis in vitro.
作者信息
Calzado M C, Garcia-Castellano J M, Manzanares R M, Martinez F, Prieto B, Torres A
出版信息
Br J Pharmacol. 1982 Feb;75(2):301-3. doi: 10.1111/j.1476-5381.1982.tb08786.x.
The possible modifications in haematopoiesis induced by cimetidine were studied in normal bone marrow cultures in vitro. When cimetidine was added in the therapeutic range, there was no significant change in either granulocytic-macrophagic (CFU-GM) or erythroid (BFU-E) colony growth. However, when cimetidine was added to the culture at 2 to 25 times the therapeutic range, a small but significant inhibition of both types of colony growth was found. We conclude that cimetidine in the therapeutic range does not induce inhibition of haematopoiesis in vitro but does in doses above the therapeutic range when inhibition is dose-dependent.
在体外正常骨髓培养中研究了西咪替丁诱导的造血可能的改变。当在治疗范围内添加西咪替丁时，粒细胞-巨噬细胞（CFU-GM）或红系（BFU-E）集落生长均无显著变化。然而，当以治疗范围的2至25倍将西咪替丁添加到培养物中时，发现两种集落生长均受到轻微但显著的抑制。我们得出结论，治疗范围内的西咪替丁在体外不会诱导造血抑制，但在高于治疗范围的剂量下会诱导抑制，且抑制呈剂量依赖性。
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