Posnett D N, Stein R S, Graber S E, Krantz S B
Arch Intern Med. 1979 May;139(5):584-6.
Neutropenia associated with high-dose cimetidine therapy developed in a patient in whom earlier therapy, as well as rechallenge with low-dose cimetidine, did not result in neutropenia. As other factors cannot be implicated, a dose-related toxicity of cimetidine appears likely. Although the mechanism of cimetidine-induced neutropenia is unknown, it may involve the previously demonstrated ability of histamine H2 receptor antagonists to block the histamine-induced initiation of DNA synthesis in bone marrow stem cells.
一名患者在接受高剂量西咪替丁治疗时出现了中性粒细胞减少症，而该患者早期接受治疗以及再次接受低剂量西咪替丁治疗时均未出现中性粒细胞减少症。由于无法确定其他相关因素，西咪替丁的剂量相关毒性似乎是可能的。虽然西咪替丁诱导中性粒细胞减少症的机制尚不清楚，但可能涉及组胺H2受体拮抗剂先前已被证实的阻断组胺诱导骨髓干细胞DNA合成起始的能力。
